Aronem® IV is the preparation of Meropenem. It is a broad-spectrum carbapenem antibiotic for parenteral use which is active against Gram-positive and Gram- negative bacteria. It is relatively stable to human dehydropeptidase-1 (DHP-1). Meropenem exerts its bactericidal action by interfering with bacterial cell wall synthesis. The basis of the potent bactericidal action of Meropenem against a broad spectrum of aerobic and anaerobic bacteria are ease of penetration into bacterial cell walls, high level of stability to all serine β-lactamases and marked affinity for the Penicillin Binding Proteins (PBPs).
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